compounds, process for their manufacture, pharmaceutical compositions comprising them, method for treating and / or preventing diseases that are associated with h3 receptor modulation, use of the compounds, and methods for treating or preventing obesity, and Type II diabetes
MATTHIAS NETTEKOVEN,JEAN-MARC PLANCHER,HANS RICHTER,OLIVER ROCHE,SVEN TAYLOR
申请号：
BRPI0710588
公开号：
BRPI0710588A2
申请日:
2007.03.28
申请国别(地区):
BR
年份:
2012
代理人:
摘要：
COMPOUNDS, PROCESS FOR THEIR MANUFACTURE, PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM, METHOD FOR TREATING AND / OR PREVENTING SICKNESS THAT ARE ASSOCIATED WITH THE MODULATION OF H3 RECEPTORS, USE OF THE COMPOUNDS, AND METHODS OF TREATMENT OR TREATMENT OR METHODS OF TYPE II DIABETES. The present invention relates to compounds of formula 1 wherein G and R ^ 1 ^ through R ^ 5 ^ and R ^ 12 ^ are as defined in the description and in the claims, and their pharmaceutically acceptable salts. The compounds are useful for the treatment and / or prevention of diseases that are associated with the modulation of H3 receptors.COMPOSTOS, PROCESSO PARA A SUA MANUFATURA, COMPOSIçõES FARMACêUTICAS QUE OS COMPREENDEM, MéTODO PARA O TRATAMENTO E/OU PREVENçãO DE ENFERMIDADES QUE ESTAO ASSOCIADAS COM A MODULAçãO DE RECEPTORES DE H3, USO DOS COMPOSTOS, E MéTODOS PARA O TRATAMENTO OU PREVENçãO DE OBESIDADE, E DE DIABETES DO TIPO II. Refere-se a presente invenção a compostos da formula 1 em que G e R^ 1^ até R^ 5^ e R^ 12^ são tais como definidos na descrição e nas reivindicaçóes, e seus sais farmaceuticamente aceitáveis. Os compostos são de utilidade para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de H3.
