Small tissue property change detection is provided for magnetic resonance (MR) guided intervention. T1 changes from before and after treatment are compared. The comparison identifies locations of possible change. The comparison is performed for different times, one before and one after a zero-crossing of a signal intensity time curve. Due to the characteristics of the T1 mapping, common locations from the different times will have reversed contrast. Clustering and this reversal are used to distinguish the treatment region from noise.
