A system for comprehensive multisensory vision, hearing, and cognitive screening includes a headwear test unit comprising a configurable video, audio, and hand-gesture capable testing device. The system further includes an identification, anonymization and security module, a patient interface, an operator interface, a communication module, and a unit charging and calibration module and/or station. An adaptive real-time compiler compiles sequences of optometric hearing and cognition tests. A cloud-based web service module is configured for storing encrypted personal optometric information. A machine learning module is operatively connected to the cloud-based web service module.