Complex

• 收藏
• 分享

专利权人:

テンボロン オイ

发明人:

レッパネン アン,エクホルム フィリップ エス．,ヘリン ヤリ,サロ ハンナ,カネルヴァ アン,エクホルム フィリップ エス.

申请号：

JP2015119792

公开号：

JP5924795B2

申请日:

2015.06.12

申请国别(地区):

JP

年份:

2016

代理人:

摘要：

The present invention relates to a conjugate comprising an anti-EGFR1 antibody or an EGFR binding fragment thereof and at least one dextran derivative, wherein the dextran derivative comprises at least one D-glucopyranosyl unit, wherein at least one carbon selected from carbon 2, 3 or 4 of the at least one D-glucopyranosyl unit is substituted by a substituent of the formula —O—(CH2)n—S—B12H112− wherein n is in the range of 3 to 10； and the dextran derivative is bound to the anti-EGFR antibody or an EGFR1 binding fragment thereof via a bond formed by a reaction between at least one aldehyde group formed by oxidative cleavage of a D-glucopyranosyl unit of the dextran derivative and an amino group of the anti-EGFR1 antibody or an EGFR1 binding fragment thereof.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/