A pharmaceutical composition comprising metformin or pharmaceutically acceptable salts, esters, solvates, hydrates, metabolites, prodrugs or isomers thereof in extended release form and pioglitazone or pharmaceutically acceptable salts, esters, solvates, hydrates, metabolites, prodrugs or isomers thereof in immediate release form is provided. More particularly a pharmaceutical composition comprising extended release metformin core comprising metformin, extended release polymer and other pharmaceutically acceptable excipients and immediate release pioglitazone layer comprising pioglitazone, high viscosity polymer, and other pharmaceutically acceptable excipients. Further a pharmaceutical composition comprising extended release metformin core comprising metformin, extended release polymer and other pharmaceutically acceptable excipients and immediate release pioglitazone layer comprising pioglitazone, polyvinyl alcohol, surfactant and other pharmaceutically acceptable excipients
