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An inhalable dry powder formulation COMPREHENSIVE GLP-1 FOR USE IN THE TREATMENT OF HYPERGLYCAEMIA AND DIABETES BY pulmonary delivery
专利权人:
MANNKIND CORPORATION
发明人:
RICHARDSON, PETER,BAUGHMAN, ROBERT, A.,COSTELLO, DONALD
申请号:
DK08841194
公开号:
DK2211842T3
申请日:
2008.10.24
申请国别(地区):
DK
年份:
2015
代理人:
摘要:
An inhalable dry powder formulation comprising a therapeutically effective amount of a glucagon-like peptide-1 (GLP-1) for prandial use in combination with insulin for the treatment of hyperglycemia and/or diabetes in a patient. The inhalable dry powder formulation preferably comprises a diketopiperazine having the formula 2,5-diketo-3,6-di(4-X-aminobutyl)piperazine and wherein X is selected from the group consisting of succinyl, glutaryl, maleyl, and fumaryl, or a pharmaceutically acceptable salt thereof. The GLP-1 may be selected from the group consisting of native GLP-1, a GLP-1 metabolite, a GLP-1 analog, a GLP-1 derivative, a GLP-1 mimetic, an exendin, a GLP-1 peptide analog, a biosynthetic GLP-1 analog, or combinations thereof.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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