Michael Sela;Ruth Maron;Bilha Schechter;Yosef Yarden
发明人:
Michael Sela,Yosef Yarden,Bilha Schechter,Ruth Maron
申请号：
US14118243
公开号：
US09040047B2
申请日:
2012.05.16
申请国别(地区):
US
年份:
2015
代理人:
摘要：
An article-of-manufacture is provided. The article-of-manufacture comprises a packaging material identified for treating cancer, packaging:(i) an anti-EGFR antibody comprising the CDR sequences of anti EGFR 565 (CNCM Deposit Number I-4262)； and(ii) an anti-ErbB-2 antibody comprising the CDR sequences of anti ErbB-2 L431 (CNCM Deposit Number I-4115), anti ErbB-2 L26 (CNCM Deposit Number I-4113) or anti ErbB-2 N12 (CNCM Deposit Number I-4112),or(iii) an anti-EGFR antibody comprising the CDR sequences of anti EGFR 111 (CNCM Deposit Number I-4261)； and(iv) an anti-ErbB-2 antibody comprising the CDR sequences of anti ErbB-2 L431 (CNCM Deposit Number I-4115).Also provided are pharmaceutical compositions and methods of using the above antibodies as well as other antibody combinations for the treatment of cancer.
