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FIBERS COMPRISING POLYESTERAMIDE COPOLYMERS FOR DRUG DELIVERY
专利权人:
DSM IP ASSETS B.V.
发明人:
Mirian Hendrika Jacoba Gillissen-Van Der Vight,Jens Christoph Thies,George Mihov
申请号:
US14432349
公开号:
US20150240387A1
申请日:
2012.10.24
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present invention relates to fibers comprising a polyesteramide (PEA) having a chemical formula described by structural formula (IV), wherein m+p varies from 0.9-0.1 and q varies from 0.1 to 0.9, m+p+q=1 whereby m or p could be 0, n is about 5 to about 300; (pref. 50-200), —R1 is independently selected from the group consisting of (C2-C20) alkylene or (C2-C20) alkenylene and combinations thereof; —R3 and R4 in a single backbone unit m or p, respectively, are independently selected from the group consisting of hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C6-C10)aryl, —(CH2)SH, —(CH2)2S(CH3), —CH2OH, —CH(OH)CH3, —(CH2)4NH3+, —(CH2)3NHC(═NH2+)NH2, —CH2COOH, —(CH2)COOH, —CH2—CO—NH2, —CH2CH2—CO—NH2, —NH—CH2CH2COOH, CH3—CH2—CH(CH3)—, (CH3)2—CH—CH2—, H2N—(CH2)4—, Ph-CH2—, CH═C—CH2—, HO-p-Ph-CH2—, (CH3)2—CH—, Ph-NH—, NH—(CH2)3—C—, NH—CH═N—CH═C—CH2—. —R5 is selected from the group consisting of (C2-C20)alkylene, (C2-C20)alkenylene, alkyloxy or oligoethyleneglycol, —R6 is selected from bicyclic-fragments of 1,4:3,6-dianhydrohexitols of structural formula (III); —R7 is selected from the group consisting of (C6-C10)aryl (C1C6)alkyl, —R8 is —(CH2)4-; whereby a is at least 0.05 and b is at least 0.05 and a+b=1.
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