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Nitrogen-containing condensed heterocyclic compound
专利权人:
Hiroaki Tanaka;Tsuyoshi Busujima;Yoshihisa Shirasaki;Kanako Iwakiri;Takahiro Oi;Nagaaki Sato;Shigeru Tokita
发明人:
Tsuyoshi Busujima,Takahiro Oi,Hiroaki Tanaka,Yoshihisa Shirasaki,Kanako Iwakiri,Nagaaki Sato,Shigeru Tokita
申请号:
US14004950
公开号:
US09035059B2
申请日:
2012.03.14
申请国别(地区):
US
年份:
2015
代理人:
摘要:
There are provided compounds represented by the following general formula (I) or pharmaceutically acceptable salts of thereof, which have a superior monoacylglycerol acyltransferase 2 inhibitory action:whereinRing A represents a partially saturated heteroaryl group, an aryl group or a heteroaryl group,RB represents a C4-18 alkyl group, a C3-8 cycloalkyl group, a partially saturated aryl group, an aryl group, or the following formula (II):whereinV represents the formula —CR11R12—, —CO—, —CO—O—, or —CO—NH—,W represents a single bond or a C1-3 alkylene group, andRing B represents a C3-8 cycloalkyl group, a C3-8 cycloalkenyl group, a partially saturated heteroaryl group, a saturated heterocyclyl group, an aryl group, or a heteroaryl group,Y represents a nitrogen atom or the formula N+(RF),RF represents a C1-4 alkyl group, andm and n, which may be the same or different, each represent an integer of 0 or 1.
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