#$%^&*AU2020202847A120200521.pdf#####Abstract The use of a genetic method to down-regulate 5 RBO/EFR3/EFR3A/EFR3B proteins, TTC7 protein or PI4KIIIa enzyme protein which interacts with RBO/EFR3/EFR3A/EFR3B proteins and TTC7 protein, or the use of a drug to inhibit PI4KIIIa protein kinase activity reduces the accumulation of Ap 4 2 within neurons and age-dependent synaptic transmission failure 10 and other obstacles in a fruit fly AD model, and obtains an effect of improving the learning and memory abilities of AD model mice. Provided is a method for using an RBO/EFR3/EFR3A/EFR3B inhibitor, a TTC7 inhibitor and a PI4KIIIa inhibitor to treat Alzheimer's disease. Also provided is a 15 method for screening a drug treating Alzheimer's disease by whether As secretion by nerve cells is promoted or not.
