David Fedida,Gregory N. Beatch,Alan M. Ezrin,Peter M. R. Orth,Christian Hesketh
申请号：
US12689909
公开号：
US08207219B2
申请日:
2010.01.19
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Methods, compositions, dosing regimes, and routes of administration for the treatment or prevention of arrhythmias. In these methods, early afterdepolarizations and prolongation of QT interval may be reduced or eliminated by administering ion channel modulating compounds to a subject in need thereof. The ion channel modulating compounds may be cycloalkylamine ether compounds, particularly cyclohexylamine ether compounds. Also described are compositions of ion channel modulating compounds and drugs which induce early afterdepolarizations, prolongation of QT interval and/or Torsades de Pointes.
