LADEL Christoph H;BAY-JENSEN Anne-Christine;Merck Patent GmbH;KARSDAL Morten;QVIST Per;GUEHRING Hans
发明人:
GUEHRING Hans,LADEL Christoph H,BAY-JENSEN Anne-Christine,KARSDAL Morten,QVIST Per
申请号：
IL27357420
公开号：
IL273574D0
申请日:
2020.03.24
申请国别(地区):
IL
年份:
2020
代理人:
摘要：
The present invention relates to biomarkers associated with the clinical response to an FGF-18 compound before or during treatment of a cartilage disorder. It relates more particularly to specific proteins present in the blood, serum, synovial fluid or in the urine, which can be used as biomarkers for the diagnosis, pre-treatment of patients and during therapy of cartilage disorders. The invention can be used in predicting the response to an FGF-18 compound treatment, before starting the treatment or during the treatment. It could be used for selecting/identifying subjects to be treated according to specific doses and/or dosing regimens by intra-articular administration of an FGF-18 compound. The use of these biomarkers in diagnostics could result in increased benefit and reduced risk-benefit ratio in subjects.
