Satoshi Inoue,Hui Ding,Eggehard Holler,Keith L. Black,Julia Y. Ljubimova
申请号：
US16773769
公开号：
US20200155593A1
申请日:
2020.01.27
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Nanobiopolymeric conjugates based on biodegradable, non-toxic and non-immunogenic poly (β-L-malic acid) PMLA covalently linked to molecular modules that include morpholino antisense oligonucleotides (AONa), an siRNA or an antibody specific for an oncogenic protein in a cancer cell, and an antibody specific for a transferrin receptor protein, are provided. Methods for treating a cancer in subject with nanobiopolymeric conjugates are described.
