INDUSTRY-ACADEMIC COOPERATION FOUNDATION; YONSEI UNIVERSITY
发明人:
HEO, Ji Hoe,허지회,KWON, Il,KIM, Young Dae,김영대,HONG, Sung Yu,홍성유
申请号：
KRKR2011/008248
公开号：
WO2012/060607A3
申请日:
2011.11.01
申请国别(地区):
WO
年份:
2012
代理人:
摘要：
The present invention relates to: a composition for dissolving thrombi comprising a peptide comprising the Arg-Gly-Asp motif a pharmaceutical composition for treating stenotic or occlusive vascular diseases which comprises the same and a thrombus dissolving method and a method for treating stenotic or occlusive vascular diseases, comprising the step of administering the same. The compositions and methods of the present invention have the advantage that they effectively break down already formed thrombi by adopting the principle of targeting integrin within the thrombus such as platelet surface GPIIb-IIIa, which is not the same as the existing principle of plasminogen activation. Also, the compositions and methods of the present invention have a nerve-protecting function as they effectively open as far as the microvasculature, without the occurrence of restenosis after penetration.La présente invention concerne : une composition pour la dissolution de thrombi, comprenant un peptide comprenant le motif Arg-Gly-Asp une composition pharmaceutique pour le traitement de maladies vasculaires sténotiques ou occlusives qui la comprend et un procédé de dissolution de thrombus et une méthode de traitement de maladies vasculaires sténotiques ou occlusives, comprenant létape dadministration de celle-ci. Les compositions et procédés de la présente invention ont lavantage quils détruisent efficacement des thrombi déjà formés en adoptant le principe de ciblage de lintégrine à lintérieur du thrombus, tel que le GPIIb-IIIa de surface de plaquette, qui nest pas le même que le principe existant dactivation du plasminogène. Egalement, les compositions et les procédés de la présente invention ont une fonction de neuroprotection puisquils ouvrent efficacement jusquà la microvasculature sans occurrence de resténose après la pénétration.본 발명은 Arg-Gly-Asp 모티프(motif)를 포함하는 펩타이드를 포함하는 혈전 용해용 조성물, 이를 포함하는 혈관 협착 또는 폐색성 질환의 치료용 약제학적 조성물, 그리고 이를 투여하는 단계를 포함하는 혈전 용해방법 및 혈관 협착 또는 폐색성 질환의 치료방법에 관한 것이
