WU, CHENGBIN,GHAYUR, TARIQ,DIXON, RICHARD W,SALFELD, JOCHEN G
申请号：
NZ59716806
公开号：
NZ597168A
申请日:
2006.08.18
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
597168 DUAL VARIABLE DOMAIN IMMUNOGLOBIN AND USES THEREOF Provided is a binding protein comprising first and second polypeptide chains, wherein said first polypeptide chain comprises VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first immunoglobulin heavy chain variable domain, VD2 is a second immunoglobulin heavy chain variable domain, C is an immunoglobulin constant domain, X1 is a linker with the proviso that it is not an immunoglobulin constant domain, and X2 is an Fc region； and said second polypeptide chain comprises VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first immunoglobulin light chain variable domain, VD2 is a second immunoglobulin light chain variable domain, C is an immunoglobulin constant domain, X1 is a linker with the proviso that it is not an immunoglobulin constant domain, and X2 is an Fc region； wherein n is 0 or 1； and wherein the first and second polypeptide chains form two functional antigen binding sites.
