Brooks, David,Goetsch, Liliane,Zhang, Zhi-Qiang,Corvaia, Nathalie,Chastain, Michael
申请号：
AU2014262182
公开号：
AU2014262182A1
申请日:
2014.11.11
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
#$%^&*AU2014262182A120141127.pdf#####IGF-1 R SPECIFIC ANTIBODIES USEFUL IN THE DETECTION AND DIAGNOSIS OF CELLULAR PROLIFERATIVE DISORDERS Abstract The present invention relates to mammalian antibodies, designated 12B1 and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), preferably human IGF-IR. Also included are chimeric, bispecific, derivatized, single chain antibodies derived from the antibodies disclosed herein. Nucleic acid molecules encoding the mammalian antibodies as well as methods of use thereof are also disclosed. Also included are pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for treatment and diagnosis of pathological hyperproliferative oncogenic disorders associated with expression of 1 Gf-1 R. (4471111 11-M(-H
