VAN DONGEN, MARIA,JURASZEK, JAROSLAW,SCHEPENS, WIM BERT GRIET,LAWSON, EDWARD CHARLES,SHOOK, BRIAN C,JONCKERS, TIM HUGO MARIA,TAHRI, ABDELLAH,RABOISSON, PIERRE JEAN-MARIE BERNARD,BUYCK, CHRISTOPHE FRAN
申请号：
CA3052353
公开号：
CA3052353A1
申请日:
2018.02.01
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention provides piperazine derivatives exhibiting high affinity to the stem region (viral membrane proximal part) of influenza hemagglutinin as determined through competition binding and high virus neutralization activity while having low cytotoxity. Furthermore, the present invention relates to pharmaceutical compositions comprising said piperazine derivatives, methods of preparing said piperazine derivatives, as well as said piperazine derivatives for use in medical prevention or treatment, especially for preventing or treating influenza.
