A direct neural interface system comprised of electrodes for acquiring electrophysiological signals representative of a neuronal activity of a subjects brain a pre-processor for conditioning, digitizing and preprocessing the electrophysiological signals a processor for processing the digitized and preprocessed electrophysiological signals and generating command signals and an output for outputting said command signals wherein the processor is adapted for: representing the electrophysiological signals acquired over an observation time window in the form of a N-way data tensor, N being greater or equal to three and generating command signals corresponding to the observation time window by applying a multi-way regression model over the data tensor. A method of calibrating the direct neural interface system.
