新穎的膜鐵運輸蛋白(FERROPORTIN)抑制劑农业专利-农业专业知识服务系统

发明人:: DURRENBERGER, FRANZ,杜伦伯格　法兰兹,杜倫伯格　法蘭茲,BURGERT, MICHAEL,包格特　麦可,包格特　麥可,KALOGERAKIS, ARIS,卡楼格阿奇斯　阿瑞斯,卡樓格阿奇斯　阿瑞斯,BUHR, WILM,包尔　沃姆,包爾　沃姆,REIM, STEFAN,瑞米　史蒂芬,MANOLOVA, VANIA,玛诺洛华　瓦尼亚,瑪諾洛華　瓦尼亞,BURCKHA,杜伦伯格法兰兹,杜倫伯格法蘭茲,包格特麦可,包格特麥可,卡楼格阿奇斯阿瑞斯,卡樓格阿奇斯阿瑞斯,包尔沃姆,包爾沃姆,瑞米史蒂芬,玛诺洛华瓦尼亚,瑪諾洛華瓦尼亞

摘要：: The invention relates to novel compounds of the general formula (I), with Het-2 being an optionally substituted bicyclic heteroaryl of the formula pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for the use as ferroportin inhibitors, more particularly for the use in the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, such as particularly iron overload states such as in particular thalassemia and hemochromatosis.本發明係關於通式(I)之新穎化合物，且Het-2為下式之任擇地經取代之雙環雜芳基包含彼等的藥學組成物及彼等作為醫藥品，尤其是作為膜鐵運輸蛋白抑制劑的用途，更尤其是用於預防及/或治療疾病缺乏鐵調素(hepcidin)所造成的疾病或鐵代謝病症，例如尤其是鐵過載狀態，例如尤其是地中海貧血和血色素沉著症的用途。