The invention relates to novel compounds of the general formula (I), with Het-2 being an optionally substituted bicyclic heteroaryl of the formula pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for the use as ferroportin inhibitors, more particularly for the use in the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, such as particularly iron overload states such as in particular thalassemia and hemochromatosis.本發明係關於通式(I)之新穎化合物,且Het-2為下式之任擇地經取代之雙環雜芳基包含彼等的藥學組成物及彼等作為醫藥品,尤其是作為膜鐵運輸蛋白抑制劑的用途,更尤其是用於預防及/或治療疾病缺乏鐵調素(hepcidin)所造成的疾病或鐵代謝病症,例如尤其是鐵過載狀態,例如尤其是地中海貧血和血色素沉著症的用途。