For COPD assessment in medical imaging, imaging data is used to model (14) airways and to extract (17) values for features representative of COPD. The airway model provides values for anatomy of the airways and/or airflow. The values of anatomy, airflow, and/or extracted image features in combination indicate (17) COPD information. A machine-learned model (45) may be used to relate the anatomy, airflow, and/or extracted image features to the COPD information. Additional information may be used, such as spirometry results and/or questionnaire answers. The combination of information, including airway modeling (14), as input to a COPD model may provide a more comprehensive understanding of COPD for assistance in therapy and/or diagnosis of a particular patient.
