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תכשיר בדיקת הדמית טאו
专利权人:
CLINO LTD.
发明人:
申请号:
IL22588813
公开号:
IL225888A
申请日:
2013.04.22
申请国别(地区):
IL
年份:
2017
代理人:
摘要:
An object of the present invention is to provide a probe for imaging a ²-sheet structure protein which can be used for the diagnosis of conformational diseases, particularly disease (tauopathy) having a cardinal symptom such as intracerebral accumulation of tau protein, for example, Alzheimer's disease. Another object of the present invention is to provide a compound which is highly specific to tau and can image tau with satisfactory sensitivity, and also has high brain transition, low or non-recognized bone-seeking properties and low or non-recognized toxicity. According to the present invention, the above problems are solved by providing a compound of a formula I (wherein A, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R a and R b are as defined in the present description) or a pharmaceutically acceptable salt or solvate thereof.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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