CAMERON CHUCK-MUNN LEE,CHANDRA VARGEESE,CRYSTAL BYERS,GABRIEL GRANT GAMBER,JEREMY LEE BARYZA,JUNPING ZHAO,KEITH BOWMAN,LAURA WEST,RITESH BHANUDASJI TICHKULE,ROHAN ERIC JOHN BECKWITH,SHUANGXI WANG,TANZ
申请号：
BR112015021791
公开号：
BR112015021791A2
申请日:
2014.03.06
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
abstract: this invention provides for a compound of formula (i): or a pharmaceutically acceptable salt thereof, wherein r1-r4, l and x are defined herein. the compounds of formula (i) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues. (fr) This invention concerns a composition of formula (I): or a pharmaceutically acceptable cellulose, R1-R4, L and X. The formulations of formula (I) and pharmaceutically acceptable compounds of cation-based lipids without cationic agents useful in the administration of biologically active principles to cells and tissues. -------------------------------------------------- -------------------------------------------------- - Translation of abstract patent summary: "Lipids and lipid compositions for the release of active agents". This invention provides a compound of formula (1): or a pharmaceutically acceptable salt thereof, wherein r1 - r4, 1 and x are defined herein. The compounds of formula (1) and pharmaceutically acceptable salts thereof are cationic lipids useful in releasing biologically active agents to cells and tissues.abstract: this invention provides for a compound of formula (i): or a pharmaceutically acceptable salt thereof, wherein r1-r4, l and x are defined herein. the compounds of formula (i) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues. (fr)cette invention concerne un composé de formule (i) : ou un sel pharmaceutiquement acceptable de celui-ci, r1-r4, l et x sont définis ici. les composés de formule (i) et les sels pharmaceutiquement acceptables de ceux-ci sont des lipides cationiques utiles dans l'administration de principes biologiquement actifs à des cellules et des tissus. -----------------------------------------------------------------------------------------------------tradução do resumo resumo patente de invenção: "lipídios e co
