OR, Yat Sun,MA, Jun,WANG, Guoqiang,LONG, Jiang,WANG, Bin
申请号：
ES11827336
公开号：
ES2560003T3
申请日:
2011.09.20
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of Formula VII: ** Formula ** where each of R1 ', R2', R3 'and R4' is independently R6, or R1 and R2 ', R2' and R3 'or R3' and R4 'combined together with the carbon atoms to which they are attached form an aromatic or heteroaromatic or cyclic or heterocyclic ring； - is selected from -C3-C12-cycloalkyl, substituted C3-C12-cycloalkyl； -C3-C12-cycloalkenyl, -C3-C12-substituted cycloalkenyl； -C3-C12 heterocycloalkyl and substituted C3-C12 heterocycloalkyl； or - is ** Formula ** where each of R7 and R8 is independently, C1-C8 alkyl or C2-C8 alkenyl and each is independently and optionally substituted with one or more halo； each R6 is independently selected from: (i) hydrogen； halogen； -NO2； -CN； or N3； (ii) -M-R3, where M is O, S or NH； (iii) NR4R5； (iv) -C1-C8 alkyl, -C2-C8 alkenyl or -C2-C8 alkynyl each containing 0, 1, 2 or 3 heteroatoms selected from O, S or N； -C1-C8 substituted alkyl, -C2-C8 substituted alkenyl or -C2-C8 substituted alkynyl, each containing 0, 1, 2 or 3 heteroatoms selected from O, S or N； -C3-C12 cycloalkyl, -C3-C12 substituted cycloalkyl； substituted C3-C12 cycloalkenyl or substituted C3-C12 cycloalkenyl； (v) aryl； substituted aryl； heteroaryl； or substituted heteroaryl； and (vi) heterocycloalkyl or substituted heterocycloalkyl； R3 is independently selected from C1-C8 alkyl； -C2-C8 alkenyl or -C2-C8 alkynyl, each containing 0, 1, 2 or 3 heteroatoms selected from O, S or N, -C1-C8 substituted alkyl, -C2-C8 substituted alkenyl or -C2-C8 alkynyl substituted, each containing 0, 1, 2 or 3 heteroatoms selected from O, S or N； -C3-C12 cycloalkyl, -C3-C12 substituted cycloalkyl； -C3-C12-cycloalkenyl, -C3-C12-substituted cycloalkenyl； heterocyclic； substituted heterocyclic； aryl； substituted aryl； heteroaryl； and substituted heteroaryl； each R4 and R5 is independently selected from H and R3, or R4 and R5, combined together with the nitrogen to which they are attached form a heterocyclic ring； each of R and R 'is independently selected from the
