The present invention relates to a C-arm-based medical imaging system and a method for matching 2D images and 3D spaces. The medical imaging system of the present invention includes a C-arm having an X-ray source and a detector； A first plate installed in an X-ray path between the X-ray source and the detector and having a first transmission surface provided with a plurality of first ball markers having X-ray opacity and a first optical marker； A second plate installed in an X-ray path between the X-Sir source and the detector and having a second transmission surface and a second optical marker on which a plurality of second ball markers having X-ray opacity are provided； A reference optical marker for providing a three-dimensional reference coordinate system； An optical tracking device for recognizing positions of the first and second optical markers and the reference optical marker； And obtaining a first photographed image and a second photographed image for the subject at a first position and a second position where the detectors are different from each other, and positions of the first and second ball markers on the first and second photographed images. And a matching unit for calculating a matching relationship between coordinates on a three-dimensional reference coordinate system and positions on the first and second photographed images based on the position information obtained from the optical tracking device. The present invention can derive a matching relationship between image pixel-spatial coordinates from the correlation between the minimum number of C-arm images, that is, the C-arm images acquired at least two arbitrary positions, without forming a 3D voxel. It is possible to implement spatial coordinate-based planning and navigation functions of surgery plans by using the minimum number of C-arm images with no position limit.본 발명은 C-arm 기반의 의료영상 시스템 및 2D 이미지와 3D 공간의 정합방법에 관한 것이다. 본 발명의 의료영상 시스템은 X-레이 소스 및 디텍터를 갖는 C-arm； 상기 X-레이 소스 및 상기 디텍터 사이의 X-레이
