MINGOZZI, FEDERICO,ANGUELA, XAVIER,WRIGHT, J., FRASER,HIGH, KATHERINE, A.
申请号：
HK15103023.8
公开号：
HK1202434A
申请日:
2015.03.25
申请国别(地区):
HK
年份:
2015
代理人:
摘要：
The invention provides viral vector formulations and methods of uses thereof for delivery of transgenes or therapeutic nucleic acids to human subjects. The formulations include a vector and suitable amounts of empty capsids, viral genome-containing capsids, or viral capsid proteins which are optionally chemically or structurally modified and which bind to neutralizing anti- AAV antibodies thereby reducing or preventing antibody-mediated clearance of the vector, but still allowing the genome-containing (therapeutic) vector to transduce target cells and achieve therapeutic gene transfer.
