Claire Ashman,Ian Richard Catchpole,Zoe Hughes-Thomas,Alan Peter Lewis,Michael Steward
申请号：
US14235330
公开号：
US09499612B2
申请日:
2012.07.25
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain Fc region of an antibody, wherein each epitope binding domain in capable of binding to VEGF, to dimers comprising two antigen binding constructs of the invention, pharmaceutical compositions comprising said dimers and their use in the treatment of diseases associated with VEGF signalling, such as diabetic macular edema (DME), wet age-related macular degeneration (Wet AMD), diabetic retinopathy, retinal vein occlusion (RVO), and corneal neovascularization, and polynucleotide sequences encoding said antigen binding constructs.
