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SUBSTITUTED HETEROCYCLES AND THEIR USE AS ALLOSTERIC MODULATORS OF NICOTINIC AND GABAA RECEPTORS
专利权人:
Timothy B.C. Johnstone;Kelvin W. Gee;Dark J. Hogenkamp
发明人:
Timothy B.C. Johnstone,Dark J. Hogenkamp,Kelvin W. Gee
申请号:
US13255781
公开号:
US20120077816A1
申请日:
2010.03.09
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention is related to heterocycles represented by a compound of Formula I that are novel allosteric modulators of α7 nAChRs and/or GABAA receptors. The invention also discloses the treatment of disorders that are responsive to enhancement of acetylcholine action on α7 nAChRs and negative allosteric modulation of GABAA receptors in a mammal by administering an effective amount of a compound of Formula I.
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