PROBLEM TO BE SOLVED: To provide a method of driving a balloon by an IABP driving device capable of preventing formation of a thrombus on a balloon surface. [Solution] A method of driving a balloon by an IABP driving device that attaches a balloon catheter to which a balloon is connected and expands and contracts the balloon, wherein the balloon is continuously synchronized with a heartbeat having a heart rate of 120 bpm or more, and When performing high-speed continuous driving to drive, if the high-speed continuous driving continues for a predetermined time of 30 seconds or more, after performing a resting operation of maintaining the balloon in a contracted state for a predetermined number of heartbeats, the high-speed continuous driving is performed again Perform continuous drive. [Selection diagram] FIG.【課題】 バルーン表面における血栓の形成を防止し得るIABP駆動装置によるバルーンの駆動方法。【解決手段】 バルーンが接続されたバルーンカテーテルを取り付け、前記バルーンを拡張及び収縮させるIABP駆動装置によるバルーンの駆動方法であって、心拍数が120bpm以上である心拍に対して連続的に同期して、前記バルーンを駆動する高速連続駆動を行う際、前記高速連続駆動が30秒間以上の所定時間続くと、所定の回数の心拍に対して前記バルーンを収縮状態に維持する休拍動作を行った後、再び前記高速連続駆動を行う。【選択図】図5