Robert Eugene Hormann,David W. Potter,Orestes Chortyk,Colin M. Tice,Glenn Richard Carlson,Andrew Meyer,Thomas R. Opie
申请号：
US13954376
公开号：
US09359289B2
申请日:
2013.07.30
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain； a ligand binding domain； a transactivation domain； and a ligand is contacted with a DNA construct comprising； the exogenous gene and a response element； wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
