PROBLEM TO BE SOLVED: To provide a soft gelatin capsule containing a pharmaceutical formulation comprising at least one omega-3 polyunsaturated fatty acid in free acid form or a pharmacologically acceptable derivative thereof.SOLUTION: A pharmaceutical formulation comprising at least one omega-3 polyunsaturated fatty acid in free acid form or a pharmacologically acceptable derivative thereof is contained in a soft gelatin capsule characterized in that the capsule does not harden significantly over time, thus has a longer shelf life, and comprises gelatin extracted by an extraction process comprising a step of acid pre-treatment of a collagen source.【課題】オメガ－３多価不飽和脂肪酸の遊離酸型又は薬理学的に許容されるその誘導体の少なくとも一つを含む医薬製剤を有する軟ゼラチンカプセルの提供。【解決手段】オメガ－３多価不飽和脂肪酸の遊離酸型又は薬理学的に許容されるその誘導体の少なくとも一つを含む医薬製剤が、長期に亘り顕著に硬くなることが無く、有効期限がより長くなることを特徴とする、コラーゲン源の酸による前処理工程を含む抽出プロセスによって抽出されたゼラチンを含む軟ゼラチンカプセル。【選択図】なし
