A novel class of mixed micelles formed with critical micelle concentration (Cmc) characters diblock copolymer, and temperature-sensitive characters diblock copolymer were disclosed. The mixed micelles possess complementary effects in adjusting external temperature shift (storage vs. body temperature) and concentration change (dilution after intravenous injection). The mixed micelles of the present invention can serve as a potential injectable drug delivery system for anticancer drugs, such as doxorubicin and many others.