The present invention is directed to the anti-LAG-3 antibodies, LAG-3 mAb 1, LAG-3 mAb 2, LAG-3 mAb 4, LAG-3 mAb 5, and LAG-3 mAb 6, and to humanized and chimeric versions of such antibodies. The invention additionally pertains to LAG-3-binding molecules that comprise LAG-3 binding fragments of such anti-LAG-3 antibodies, immunocongugates, and to bispecific molecules, including diabodies, BiTEs, bispecific antibodies, etc., that comprise (i) such LAG-3-binding fragments, and (ii) a domain capable of binding an epitope of a molecule involved in regulating an immune check point present on the surface of an immune cells. The present invention also pertains to methods of detecting LAG-3, as well as methods of using molecules that bind LAG-3 for stimulating immune responses.本發明涉及抗LAG-3抗體LAG-3 mAb 1、LAG-3 mAb 2、LAG-3 mAb 4、LAG-3 mAb 5和LAG-3 mAb 6，以及涉及這類抗體的人源化和嵌合形式。本發明另外涉及結合LAG-3的分子，其包括這類抗LAG-3抗體的結合LAG-3的片段、免疫連接物，並且涉及包括(i)這類結合LAG-3的片段，和(ii)能夠結合參與調節免疫細胞的表面上存在的免疫檢查點的分子的表位元的結構域的雙特異性分子，包括雙抗體、BiTE、雙特異性抗體等。本發明也涉及檢測LAG-3的方法，以及使用結合LAG-3的分子用於刺激免疫應答的方法。
