The present invention provides octahydro fused azadecalin compounds having glucocorticoid receptor binding affinity and modulatory activity for pharmaceutical use. Also provided are pharmaceutical compositions containing an effective amount of the fused azadecalin compounds and methods of using the compositions for the-treatment of a glucocorticoid receptor mediated disorder in a subject.La presente invención provee compuestos de azadecalina octahidrofusionada y métodos para usar los compuestos como moduladores de receptores de glucocorticoides.