Provided herein are various embodiments relating to antibodies. Some of the embodiments include antagonist antibodies that bind PD-1. Such antibodies can be used in methods to treat, for example, cancer.本文提供關於抗體之各種實施例。一些實施例包括結合PD-1之拮抗劑抗體。此類抗體可用於治療例如癌症之方法中。