PROCÉDÉS POUR LA MISE AU POINT ET L'UTILISATION D'UNITÉS DE MICRO-AGRÉGATS CELLULAIRES FONCTIONNELS POLARISÉS DE MANIÈRE MINIMALE DANS DES APPLICATIONS TISSULAIRES À L'AIDE DE CELLULES SOUCHES ÉPITHÉLIALES EXPRIMANT LGR4, LGR5 ET LGR6
Provided herein are constructs of micro-aggregate multicellular, minimally polarized grafts containing Leucine-rich repeat-containing G-protein coupled Receptor (LGR) expressing cells for wound therapy applications, tissue engineering, cell therapy applications, regenerative medicine applications, medical/therapeutic applications, tissue healing applications, immune therapy applications, and tissue transplant therapy applications which preferably are associated with a delivery vector/substrate/support/scaffold for direct application.