The present disclosure provides animal feed supplements comprising a therapeutically effective amount of monensin, a solvent, and a mineral mix, wherein the mineral mix is substantially free of monocalcium phosphate. In addition, the present dis - closure provides processes of preparing animal feed supplements and animal food compositions comprising such animal feed supple ments. The present disclosure provides animal feed supplements comprising a therapeutically effective amount of monensin, a solvent, and an alkaline component. In addition, the present disclosure provides animal food compositions containing such animal feed supplements, and methods for their use.