YIM, JOUNG HANKR,임정한,KIM, IL CHANKR,김일찬,HAN, SE JONGKR,한세종,YOUN, UI JOUNGKR,윤의중,OH, HYUN CHEOLKR,오현철,SOHN, JAE HAKKR,손재학,KIM, YOUN CHULKR,김윤철,LEE, HO SUBKR,이호섭,KANG, DAE GILKR,강대길,TRAN HONG QUANGVN,트란
申请号：
KR1020160067763
公开号：
KR1017238710000B1
申请日:
2016.05.31
申请国别(地区):
KR
年份:
2017
代理人:
摘要：
The present invention relates to a pharmaceutical composition which is used for preventing or treating inflammatory diseases and comprises 3,7-dimethyl-1,8-dihydroxy-6-methoxyisochroman as an active ingredient, wherein the 3,7-dimethyl-1,8-dihydroxy-6-methoxyisochroman can be isolated from the marine fungus Penicillium sp. SF-6013. According to the present invention, the pharmaceutical composition for preventing or treating inflammatory diseases comprising 3,7-dimethyl-1,8-dihydroxy-6-methoxyisochroman suppresses, with regard to inflammatory reaction, the formation of pro-inflammatory cytokines and mediators in RAW264.7 macrophages and BV2 microglial cells, and has no cytotoxicity, and thus may be beneficially used to prevent or treat inflammatory diseases.COPYRIGHT KIPO 2017본 발명은 3,7-디메틸-1,8-디히드록시-6-메톡시이소크로만을 유효성분으로 함유하는 염증성 질환 예방 또는 치료용 약학 조성물에 관한 것으로서, 3,7-디메틸-1,8-디히드록시-6-메톡시이소크로만은 해양 진균 Penicillium sp. SF-6013에서 분리될 수 있다. 본 발명에 따른 3,7-디메틸-1,8-디히드록시-6-메톡시이소크로만을 유효성분으로 함유하는 염증성 질환 예방 또는 치료용 조성물은, 염증반응과 관련하여 RAW264.7 대식세포와 BV2 미세아교세포에서 전염증성 사이토카인 및 매개체 생성을 억제하고, 세포독성이 없으므로 염증성 질환의 예방 또는 치료용도로 유용하게 사용될 수 있다.
