The present invention relates to: a novel pyrazine derivative that is represented by formula (I) and is useful as a therapeutic agent or preventive agent for diseases involving URAT1, such as gout, hyperuricemia, hypertension, kidney diseases such as interstitial nephritis, diabetes, arteriosclerosis, or Lesch-Nyhan syndrome or a pharmaceutically acceptable salt of said derivative or a solvate of said derivative or salt. (The symbols in the formula are as defined in the description.).La presente invención se refiere a: un derivado de pirazina novedoso que se representa por la siguiente Fórmula (I) y es útil como un agente terapéutico o agente preventivo para enfermedades que involucran URAT1, tal como gota, hiperuricemia, hipertensión, enfermedades renales tales como nefritis intersticial, diabetes, arterosclerosis, o síndrome de Lesch-Nyhan o una sal farmacéuticamente aceptable del derivado o un solvato de tal derivado o sal. (Los símbolos en la fórmula son como se define en la descripción.
