BONNIN, DUSTAN,ZANELLI, ERIC,KRIEGER, JEFF,MATHERS, THOMAS
申请号：
NZ58536708
公开号：
NZ585367A
申请日:
2008.10.16
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is a process for manufacturing a composition comprising directed-sequence polymers (DSPs) useful for eliciting immune responses in a subject, comprising the steps of: Selecting a first base peptide sequence, wherein the sequence is an amino acid sequence of an epitope of an antigen associated with a disease treatable by or preventable by vaccination against the epitope and wherein the length of the sequence is at least 6 amino acids； Synthesizing by solid-phase peptide synthesis a first cassette of the DSPs, the cassette having a sequence of amino acid positions corresponding to each amino acid of the first base peptide sequence, wherein for at least one amino acid position of the first cassette, an amino acid is added, the amino acid for each said position being randomly selected from a mixture of amino acids consisting of the original amino acid found at that amino acid position, optionally alanine (A), and optionally, at least one conserved substitution. The composition is capable of inducing an immune response against the base peptide sequence.
