KSP `161 inhibitor for use in the treatment of pathogenic cells in a state of mitotic arrest induced by` 161 KSP inhibitor, to increase cell apoptosis, in which the `161 KSP inhibitor is selected from 2 - (3-aminopropyl) -5- (3-fluorophenyl) -N- (2-methoxyethyl) -N-methyl-2-phenyl-1,3,4-thiadiazol-3 (2H) -carboxamide, 2- (3 -aminopropyl) -5- (3-fluorophenyl) -N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazol-3 (2H) -carboxamide, 2- (3- aminopropyl) -5- ( 2,5-difluorophenyl) -N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazol-3 (2H) -carboxamide, (S) -2- (3-aminopropyl) -5- (2 , 5-difluorophenyl) -N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazol-3 (2H) -carboxamide, (R) -2- (3-aminopropyl) -5- (2, 5- difluorophenyl) -N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazol-3 (2H) -carboxamide, and 2- (3-aminopropyl) -5- (2,5-difluorophenyl) -N10 hydroxy-N-methyl-2-phenyl-1,3,4-thiadiazol-3 (2H) -carboxamide.Inhibidor `161 de KSP para su uso en el tratamiento de células patogénicas en un estado de detención mitótica inducida por inhibidor `161 de KSP, para incrementar la apoptosis de las células, en el que el inhibidor `161 de KSP se selecciona de entre 2-(3-aminopropil)-5-(3-fluorofenil)-N-(2-metoxietil)-N-metil-2-fenil-1,3,4-tiadiazol-3(2H)- carboxamida, 2-(3-aminopropil)-5-(3-fluorofenil)-N-metoxi-N-metil-2-fenil-1,3,4-tiadiazol-3(2H)-carboxamida, 2-(3- aminopropil)-5-(2,5-difluorofenil)-N-metoxi-N-metil-2-fenil-1,3,4-tiadiazol-3(2H)-carboxamida, (S)-2-(3-aminopropil)-5- (2,5-difluorofenil)-N-metoxi-N-metil-2-fenil-1,3,4-tiadiazol-3(2H)-carboxamida, (R)-2-(3-aminopropil)-5-(2,5- difluorofenil)-N-metoxi-N-metil-2-fenil-1,3,4-tiadiazol-3(2H)-carboxamida, y 2-(3-aminopropil)-5-(2,5-difluorofenil)-N10 hidroxi-N-metil-2-fenil-1,3,4-tiadiazol-3(2H)-carboxamida.
