NKT-CELL SUBSET FOR IN VIVO PERSISTENCE AND THERAPEUTIC ACTIVITY AND PPROPAGATION OF SAME

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专利权人:

BAYLOR COLLEGE OF MEDICINE

发明人:

METELITSA, Leonid S.,COURTNEY, Amy N.,TIAN, Gengwen

申请号：

SG11201708600R

公开号：

SG11201708600RA

申请日:

2016.04.21

申请国别(地区):

SG

年份:

2017

代理人:

摘要：

Embodiments of the disclosure include methods and compositions for producing NKT cells effective for immunotherapy and also methods and compositions for providing an effective amount of NKT cells to an individual in need of immunotherapy. In specific embodiments, the NKT cells are CD62L+ and have been exposed to one or more costimulatory agents to maintain CD62L expression. The NKT cells may be modified to incorporate a chimeric antigen receptor, in some cases.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/