METELITSA, Leonid S.,COURTNEY, Amy N.,TIAN, Gengwen
申请号:
SG11201708600R
公开号:
SG11201708600RA
申请日:
2016.04.21
申请国别(地区):
SG
年份:
2017
代理人:
摘要:
Embodiments of the disclosure include methods and compositions for producing NKT cells effective for immunotherapy and also methods and compositions for providing an effective amount of NKT cells to an individual in need of immunotherapy. In specific embodiments, the NKT cells are CD62L+ and have been exposed to one or more costimulatory agents to maintain CD62L expression. The NKT cells may be modified to incorporate a chimeric antigen receptor, in some cases.