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Method of measuring efficacy of treatment for multiple sclerosis
专利权人:
Vium; Inc.
发明人:
Daniel J. Ford,Laura Schaevitz
申请号:
US15282364
公开号:
US10420503B2
申请日:
2016.09.30
申请国别(地区):
US
年份:
2019
代理人:
摘要:
A method of measuring efficacy of treatment of multiple sclerosis (MS) in an animal in a vivarium is described. Animal activity data is collected at multiple times during the night. Sequential time regions of the night are identified as high-activity, activity-drop, or low-activity regions. Embodiments are described to quantify a drop, during the night, of an animal's activity level. These quantified activity-drop scalars for consecutive nights are accumulated in an animal health dataset. This dataset is compared to healthy animals or a standard of care to determine efficacy. One embodiment quantifies an activity-drop by fitting straight-line curves through the data in the three nightly regions. Another embodiment uses a Fourier transform on a circle and a linear combination. Another embodiment compares areas under data curves in the regions. Animals may be housed in cages with other animals.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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