COMPOSES DE 6,7-DIHYDROPYRAZOLO[1,5-.ALPHA.]PYRAZIN-4(5H)-ONE ET LEUR UTILISATION EN TANT QUE MODULATEURS NEGATIFS ALLOSTERIQUES DES RECEPTEURS METABOTROPIQUES DU MGLUR2
CONDE-CEIDE, SUSANA,VAN GOOL, MICHIEL LUC MARIA,MARTIN-MARTIN, MARIA LUZ
申请号：
CA2954222
公开号：
CA2954222A1
申请日:
2015.07.30
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 2 ("mGluR2"). The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention or treatment of disorders in which the mGluR2 subtype of metabotropic receptors is involved.
