1. A humanized antibody or any antigen binding fragment thereof that specifically binds a polypeptide comprising SEQ ID NO: 15, the humanized antibody comprising: a) a heavy chain variable region that includes Cys at position H22, Ser at H23, Gly at H26 , Phe in H27, Ser in H28, Leu in H29, Ser in H30, Thr in H31, Ser in H32, Asn in H33, Met in H34, Gly in H35, Val in H35A, Gly in H35B, Leu in H48, His in H50, Not in H51, Leu in H52, Trp in H53, Asn in H54, Asp in H55, Ser in H56, Lys in H57, Tyr in H58, Tyr in H59, Asn in H60, Pro in H61, Ala in H62 , Leu in H63, Lys in H64, Ser in H65, Cys in H92, Met in H95, Gly in H96, Gly in H97, Tyr in H98, Tyr in H99, Gly in H100. Asn in H100A, Tyr in H100B, Gly in H100C, Tyr in H100D, Tyr in H100E, Ala in H100F, Met in H100G, Asp in H101 and Tyr in H102, and, optionally, at least one Leu in H49 Tyr in H74, Not in H11, Ser in H41 and Ser in H108； and b) a light chain variable region that includes Gln at position L1, Cys at L23, Thr at L24, Ala at L25, Ser at L26, Ser at L27, Ser at L27A, Val at L28, Ser at L29, Ser at L30, Ser at L31, Tyr at L32, Leu at L33, His at L34, Trp at L47, Ser at L50, Thr at L51, Ser at L52, Asn at L53, Leu at L54, Ala at L55, Ser at L56, Tyr at L71, Cys in L88, His in L89, Gln in L90, Tyr in L91, His in L92, Arg in L93, Ser in L94, Pro in L95, Pro in L96 and Thr in L97 and optionally at least one from Met to L21, Not to L10 and Ala to L80, where these positions are determined according to the Kabat numbering system. 2. The humanized antibody of claim 1, comprising: a) a heavy chain variable region that is at least about 70% identical to SEQ ID NO. one； and b) a light chain variable region that is at least about 70% identical to SEQ ID NO. 2.3. The humanized antibody according to claim 2, characterized in that said variable region of the heavy chain comprises substitution in at least one position selected from the group consisting of H10, H11, H12, H13, H15, H19, H41, H49, H74, H75 , H79, H81, H82, H
