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具有PGD2受體拮抗劑活性之磺醯胺衍生物
专利权人:
LTD.;SHIONOGI & CO.
发明人:
KUGIMIYA, AKIRA,钉宫启,釘宮啟,FUJIOKA, MASAHIKO,藤冈正彦,藤岡正彥,TACHIBANA, YUKI,立花裕树,立花裕樹,MURASHI, TAKAMI,村司孝己,ONODERA, NAOHIRO,小野寺君裕
申请号:
TW099105796
公开号:
TWI445695B
申请日:
2006.09.26
申请国别(地区):
TW
年份:
2014
代理人:
摘要:
The present invention provides a pharmaceutical composition containing, as the active component, an sulfonylamide derivatives exhibiting DP receptor antagonism and provides a therapeutic agent for the allergic diseases, which contains as the active component, a compound of the following formula (II):(wherein, ring A represents an aromatic carbon ring etc.; ring B represents a nitrogen containing non-aromatic heterocycle etc.; ring C represents aromatic carbon ring etc.; R1represents carboxyl group etc.; R2independently represents a halogen atom etc.; R3represents an optionally substituted alkoxy group etc.; R4independently represents a halogen atom etc.; R5independently represents an optionally substituted alkyl group etc.; M represents sulfonyl group etc.; Y represents a single bond etc.; L1represents a single bond etc.; L2represents a single bond etc.;k represents 0, 1, 2, 3 or 4;n represent 0, 1 or 2;and q represents 0, 1, 2 or 3; when a) ring B represents a 6 membered nitrogen containing heterocycle that contains 1~2 nitrogen atom and ring C represent phenyl ring, then k is not 0 etc.), or the pharmaceutically acceptable salt or the hydrate thereof.本發明創製具有DP受體拮抗活性之磺醯胺衍生物及以該化合物為有效成分含有之醫藥組成物,提供過敏性疾病治療劑式(II):(式中環A為芳香族碳環等;環B為含氮含非芳香族雜環等;環C為芳香族碳環等;R1為羧基等;R2各自獨立為鹵素原子等;R3為可有取代之烷氧基等;R4各自獨立為鹵素原子等;R5各自獨立為可有取代之烷基等;M為磺醯基等;Y為單鍵等;L1為單鍵等;L2為單鍵等;k為0、1、2、3、或4;n為0、1、或2;及q為0、1、2、或3;但a)環B為含有1~2個氮原子之6員含氮雜環、環C為苯環時,k不為0等)之化合物、其製藥容許鹽、或其水合物。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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