Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one
Visky, Dora,Menon, Anil,Cohen, Benjamin,Lee, Thomas,Boersen, Nathan,Kreilein, Matthew Michael,Li, Ying,Parikh, Darshan K.,Liang, Xiaozhang,Xu, Jean,Leong, William Wei-Hwa
申请号：
NZ73018914
公开号：
NZ730189A
申请日:
2014.04.16
申请国别(地区):
NZ
年份:
2018
代理人:
摘要：
Provided herein are formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin- 2(1H)-one. The compound is useful for treating or preventing cancer and conditions treatable or preventable by inhibition of a kinase pathway such as the mTOP/PI3K/Akt pathway. Also disclosed is a pharmaceutical composition comprising the compound, mannitol, microcrystalline cellulose, sodium starch glycolate, silicon dioxide, stearic acid, ethylenediaminetetraacetic acid disodium salt dihydrate, and magnesium stearate.
