Generator assemblies and systems for neuromodulation therapies are disclosed herein. A generator system configured in accordance with a particular embodiment of the present technology can include a stand assembly, a generator assembly carried by the stand assembly, and a display operably coupled to the generator assembly. The generator assembly can include at least one port configured to operably couple the generator assembly to a neuromodulation device such that the generator assembly can provide radio frequency (RF) energy to the neuromodulation device. The display can be configured to indicate operating conditions of the generator system during energy delivery. The generator system can further include a user interface operably coupled to the generator assembly and configured to activate and/or modulate the RF energy.