NEWSOUTH INNOVATIONS PTY LIMITED;ST. VINCENT'S HOSPITAL SYDNEY LIMITED; INC.;CALIMMUNE;CALIMMUNE, INC.;CALIMMUNE AUSTRALIA PTY LTD
发明人:
SUZUKI, KAZUO,KELLEHER, ANTHONY DOMINIC,SYMONDS, GEOFFREY PHILLIP,AHLENSTIEL, CHANTELLE LISA EVELYN
申请号：
CA2986469
公开号：
CA2986469A1
申请日:
2016.02.15
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present disclosure provides for an expression vector comprising (i) at least one nucleic acid sequence encoding a transcriptional gene silencing element； and (ii) at least two other nucleic acid sequences selected from the group consisting of a nucleic acid sequence that encodes a nucleic acid molecule that inhibits an HIV co-receptor； a nucleic acid sequence that encodes an HIV fusion inhibitor protein； a nucleic acid sequence encoding an inhibitor of HIV replication； and a nucleic acid sequence encoding an inhibitor of viral entry. The combination of the three mechanisms in a single expression vector provides for novel means of inhibiting HIV-1.
