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PHARMACEUTICAL COMPOSITION AND METHOD FOR THE PREVENTION OF DYSBIOSES ASSOCIATED WITH ORAL ADMINISTRATION OF ANTIBIOTICS
专利权人:
DIKOVSKII ALEKSANDER VLADIMIROVICH
发明人:
DIKOVSKII ALEKSANDER VLADIMIROVICH,Диковский Александр Владимирович,DOROZHKO OLEG VALENTINOVICH,Дорожко Олег Валентинович,RUDOY BORIS ANATOLIEVICH,Рудой Борис Анатольевич
申请号:
UA2010011851
公开号:
UA98215C2
申请日:
2008.03.18
申请国别(地区):
UA
年份:
2012
代理人:
摘要:
In the first variant, the pharmaceutical composition comprises antibiotic and prebiotic in the form of oligosaccharide of a group comprising fructooligosaccharides, galactooligosaccharides, maltooligosaccharides and isomaltooligosaccharides the polymerisation degree of which ranges from 2 to 10, the particle size is equal to less than and the purity is of at least 95 %, wherein the antibiotic particle size ranges from 20 to 200 mkm and the antibiotic and oligosaccharide are contained with a mass ratio ranging from 1:1 to 1:100 respectively. In the second variant, the pharmaceutical composition comprises antibiotic which is in the form of a powder with the particle size ranging from 20 to 200 &mum and is selected form a group consisting of beta-lactams, including the combination thereof with bacterial betalactamase inhibitors, azalides, fluoroquinalones, amphenicols, glycopeptides, ansamycins, nitro-furans, phosphonic acid derivatives, cycloserine and trimetoprim. The prebiotic is in the form of a powder oligosaccharide, the polymerisation degree of which ranges from 2 to 10, the particle size is equal to less than and the purity is of at least 95 %, wherein the antibiotic and oligoficcharide are contained with a mass ratio ranging from 1:1 to 1:100 respectively. The above-mentioned compositions are used for preventing intestinal dysbiosis during antibiotic therapy and are perorally administered. The inventive composition produces a stimulating effect on intestinal lacto bacilli and bifidobacteria simultaneously inhibiting the growth and proliferation of extraneous or pathogenic micro flora.Винахід належить до медицини та стосується фармацевтичної композиції для профілактики дисбіозу кишечника в процесі антибіотикотерапії та способу профілактики дисбіозу кишечника при антибіотикотерапії. Заявлена фармацевтична композиція, за першим варіантом винаходу, містить антибіотик і пребіотик - олігосахарид групи: фруктоолігосахариди, галактоолігосахариди, ксилоолігосахариди, м
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