The present invention relates to the pyrazines derivatives as ENAC blocking agent. Specifically, the present invention relates to formula (I) compound and its officinal salts and solvate, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 have the meaning as pointed by specification, and what treatment can be used to block mediated disease by Epithelial sodium channel. The method for also describing the pharmaceutical composition comprising the compound and preparing the compound.本發明涉及作爲ENAC阻斷劑的吡嗪衍生物。具體而言，本發明涉及式（I）化合物及其可藥用鹽和溶劑化物，其中R1、R2、R3、R4、R5、R6、R7、R8、R9和R10具有如說明書中所指出的含義，其可用於治療由上皮鈉通道阻斷所介導的疾病。還描述了包含該化合物的藥物組合物以及製備該化合物的方法。
